Stroke is the second leading cause of death
Stroke causes of disability afflicting approximately 800,000 Americans each year. A reduction in the critical brain functin (CBF) below critical thresholds discriminates between salvageable penumbra and irreversible infarct core. The mantra “Time lost is brain lost” emphasizes the rate of nervous tissue loss post-stroke – 1.9 million brain cells lost every minute – and the need for immediate diagnosis and therapeutic interventions. A crucial decision in stroke patient management is the course of treatment to be prescribed: whether a patient should receive a potentially risky and costly thrombolytic intervention, or endovascular procedure and clot retrieval (mechanical thrombectomy).
However, a major setback in acquiring CT perfusion (CTP) scans is the substantial gap in the availability of equipment and facilities, given the high initial capital equipment investments and procedural costs, which have proven prohibitive for smaller hospitals and clinics. In addition, there are several other drawbacks to these techniques, including the invasive nature of injecting exogenous contrast agents, and the need for high radiation exposure dosages to ensure high-fidelity image acquisition, which is a noted concern of the FDA.
Using an innovative hybrid of multimodality imaging, state-of-the-art computational modeling, and machine learning, we offer a predictive tool based on 3D maps of cerebral perfusion and other predictive hemodynamic measures in a timely manner. This technology will constitute significant advances in the democratization of healthcare and personalized medicine due to its inexpensive accessibility and patient-specific diagnostics.