Copper’s toxicity naturally bombards microbes, offering a key to future therapeutics
Copper has been used since antiquity to kill microbes. It has also been used in things like the Bordeaux mixture to protect vineyards and potato crops. Even our bodies use copper to bombard microbes. With its inherent toxicity against microbes, copper stresses bacteria and, in the future, could provide possible new therapeutics. To develop the best therapeutics from copper, we are working to understand the context of the mechanism of action and apply that knowledge for future innovations.
This compound we're calling 240W accomplishes such eradication in just 2 hours. In other tests, 240W reduced bacterial burden in animal models as well, making it a viable candidate for a new line of therapeutic. It also works on the causative agent of Valley Fever and MRSA. Through its Asset Development program, Tech Launch Arizona has funded making derivatives of 240W, and we now have two candidates that work better in vitro and are about to start animal studies.
Given that microbial-related deaths are predicted to top all other deaths by 2050, this class of copper chelating compounds holds promise to serve as a new branch of antimicrobials.